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- Title
T-cell analysis in identical twins reveals an impaired anti-follicular lymphoma immune response in the patient but not in the healthy twin.
- Authors
Gitelson, Elena; Spaner, David; Buckstein, Rena; Franssen, Edmee; Hewitt, Karen; Lim, Megan S; Pennell, Nancy; Schultze, Joachim L; Berinstein, Neil L
- Abstract
Summary. In lymphomas an innate defect in the T-cell repertoire could account for the impaired tumour-specific immune response; alternatively, the tumour itself could exert an inhibitory effect on the immune system. To address this issue we analysed the T-cell responses against follicular lymphoma (FL) in identical twins as it can be postulated that their overall T-cell repertoire is identical. While differences between the T-cell response of the patient and the healthy twin would point to a tumour-induced T-cell unresponsiveness, impaired responses in both would point to a defective T-cell repertoire. We demonstrated an impaired tumour-specific proliferation (P = 0·035 and P = 0·013) and cytokine release (P = 0·004 and P = 0·0008) of both peripheral blood and tumour-derived T-cells, respectively, in the FL patient compared with the T-cell response of the healthy twin. Moreover, only syngeneic primed T cells were able to directly lyse unmodified FL cells of the patient. These data support previous findings in murine lymphomas and suggest that inhibitory mechanisms during tumour growth, rather than a defective T-cell repertoire, are responsible for the insufficient T-cell response in lymphoma.
- Subjects
T cells; TWINS; LYMPHOMAS; IMMUNE response
- Publication
British Journal of Haematology, 2002, Vol 116, Issue 1, p122
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1046/j.1365-2141.2002.03240.x