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- Title
Organotin Compound Derived from 3-Hydroxy-2-formylpyridine Semicarbazone: Synthesis, Crystal Structure, and Antiproliferative Activity.
- Authors
Wiecek, Joanna; Kovala-Demertzi, Dimitra; Ciunik, Zbigniew; Wietrzyk, Joanna; Zervou, Maria; Demertzis, Mavroudis A.
- Abstract
The novel diphenyltin(IV) compound [Ph2 (HyFoSc)Sn] (2), where H2HyFoSc (1) is 3-hydroxy-2-formylpyridine semicarbazone, was prepared and characterized by vibrational and NMR (¹H, 13C) spectroscopy. The structure of [Ph2 (HyFoSc)Sn] was confirmed by single-crystal X-ray crystallography. The doubly deprotonated ligand is coordinated to the tin atom through the enolic-oxygen, the azomethine-nitrogen, and phenolic-oxygen, and so acts as an anionic tridentate ligand with the ONO donors. Two carbon atoms complete the fivefold coordination at the tin(IV) center. Intermolecular hydrogen bonding, C-H → π, and π → π interactions combine to stabilize the crystal structure. Compounds 1 and 2 have been evaluated for antiproliferative activity in vitro against the cells of three human tumor cell lines:MCF-7 (human breast cancer cell line), T24 (bladder cancer cell line), A549 (nonsmall cell lung carcinoma), and a mouse fibroblast L-929 cancer cell line.
- Subjects
ORGANOTIN compounds; PYRIDINE; MOLECULAR structure; INORGANIC synthesis; X-ray crystallography; CANCER cells; HYDROGEN bonding; LIGANDS (Chemistry)
- Publication
Bioinorganic Chemistry & Applications, 2010, Vol 2010, p1
- ISSN
1565-3633
- Publication type
Article
- DOI
10.1155/2010/718606