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Identifying early markers of synaptic dysfunction in a mouse model of tauopathy: Molecular and cell biology/synaptic disruption.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.040342
By:
- Meftah, Soraya;
- Witton, Jonathan;
- Cavallini, Annalisa;
- Murray, Tracey K.;
- Jankowski, Lukasz;
- Bose, Suchira;
- Ashby, Michael;
- Brown, Jonathan T.
Publication type:
Article
ESTABLISHING MICROFLUIDIC DEVICES AS AN IN VITRO NEURONAL MODEL FOR STUDYING MOLECULAR AND FUNCTIONAL ASPECTS OF TRANSNEURONAL TAU PROPAGATION.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P963, doi. 10.1016/j.jalz.2017.06.1291
By:
- Katsikoudi, Antigoni;
- Soubrane, Camille;
- Grubisha, Olivera;
- Fouillet, Antoine;
- Cavallini, Annalisa;
- Bose, Suchira;
- O'Neill, Michael J.;
- Hutton, MIchael;
- Broad, Lisa;
- Ursu, Daniel
Publication type:
Article
AGGREGATE-SELECTIVE ANTI-TAU ANTIBODY MC-1 DEMONSTRATED ROBUST IN VITRO AND IN VIVO ACTIVITY TO NEUTRALIZE TRANSMISSIBLE TAU AND REDUCE TAU PATHOLOGY.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P592, doi. 10.1016/j.jalz.2017.07.226
By:
- Hayashi, Mansuo L.;
- Lu, Jirong;
- Wu, Su;
- Bose, Suchira;
- Ahmed, Zeshan;
- Cooper, Jane;
- Murray, Tracey K.;
- Jackson, Samuel J.;
- Cavallini, Annalisa;
- Ward, Mark;
- Driver, David;
- Goedert, Michel;
- Demattos, Ronald B.;
- O'Neill, Michael J.;
- Hutton, Michael
Publication type:
Article
DEVELOPING IN VIVO MODELS OF TAU PROPAGATION WHICH ARE RELEVANT TO HUMAN DISEASE PATHOGENESIS AND APPLICABLE TO PRE-CLINICAL DRUG DISCOVERY.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P906, doi. 10.1016/j.jalz.2017.07.321
By:
- Ahmed, Zeshan;
- Cooper, Jane;
- Kerridge, Caroline;
- Vargova, Tereza;
- Fisher, Alice;
- Murray, Tracey K.;
- Ward, Mark;
- Meftah, Soraya;
- Cavallini, Annalisa;
- Goedert, Michel;
- Hutton, Michael L.;
- Bose, Suchira;
- O'Neill, Michael J.
Publication type:
Article
CHARACTERISATION OF TAU SPECIES INVOLVED IN TAU SEEDING AND SPREAD IN CELLULAR AND ANIMAL MODELS.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P340, doi. 10.1016/j.jalz.2016.06.625
By:
- Bose, Suchira;
- Cavallini, Annalisa;
- Kerridge, Caroline;
- Cooper, Jane;
- Jackson, Samuel J.;
- Landi, Alessia;
- Cella, Claire V.;
- Falcon, Benjamin;
- Murray, Tracey K.;
- Ahmed, Zeshan;
- Goedert, Michel;
- Hutton, Michael;
- O'Neill, Michael J.
Publication type:
Article
TRANSECTION OF TARGETED AXONAL PATHWAYS INHIBITS NETWORK SPREAD OF TAU PATHOLOGY IN A P301S MODEL OF TAU PROPAGATION.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P842, doi. 10.1016/j.jalz.2016.06.1723
By:
- Ahmed, Zeshan;
- Cooper, Jane;
- Fisher, Alice;
- Jackson, Kate;
- Murray, Tracey K.;
- Cavallini, Annalisa;
- Bose, Suchira;
- Goedert, Michel;
- Hutton, Michael;
- O'Neill, Michael J.
Publication type:
Article
Characterisation of tau from p301s mouse reveals that seed competent tau comprise small fibrils composed of hyperphosphorylated tau.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2014, v. 10, p. P145, doi. 10.1016/j.jalz.2014.04.100
By:
- Bose, Suchira;
- Jackson, Samuel James;
- Landi, Alessia;
- Falcon, Benjamin;
- Murray, Tracey;
- Cooper, Jane;
- Ahmed, Zeshan;
- Cavallini, Annalisa;
- Goedert, Michel;
- O'Neill, Michael J.;
- Hutton, Michael
Publication type:
Article
Towards a small molecule inhibitor of tau exon 10 splicing: Identification of compounds that stabilise the 5'-splice site stem-loop
Published in:
2012
By:
- Craig, Peter;
- Stelzer, Andrew;
- Bae, Sung-Hun;
- Walter, Magnus;
- Bodkin, Michael;
- Smyth, Ellen;
- Cavallini, Annalisa;
- Bose, Suchira;
- Pape, Michael;
- Hutton, Michael;
- Nuthall, Hugh
Publication type:
Abstract
Chronic inhibition of the MEK/ERK pathway fails to delay disease progression in a transgenic animal model of tauopathy
Published in:
2012
By:
- Bose, Suchira;
- Cavallini, Annalisa;
- Murray, Tracey;
- Baschirotto, Lisa;
- Czilli, Dan;
- Cella, Claire;
- Ward, Mark;
- Hanmer, Jenna;
- Sims, Helen;
- Eberle, Elizabeth;
- Simmons, Aaron;
- Sossick, Sandra;
- Cramer, Jeff;
- Calligaro, David;
- Mateo, Ana;
- Bloem, Laura;
- Nuthall, Hugh;
- O'Neill, Michael;
- Davies, Peter;
- Goedert, Michel
Publication type:
Abstract
An unbiased approach to identifying tau kinases that phosphorylate tau at sites associated with early Alzheimer's disease
Published in:
2012
By:
- Bose, Suchira;
- Cavallini, Annalisa;
- Brewerton, Suzanne;
- Bell, Amanda;
- Sargent, Samantha;
- Glover, Sarah;
- Hardy, Clare;
- Moore, Roger;
- Calley, John;
- Ramachandran, Devaki;
- Poidinger, Michael;
- Davies, Peter;
- Hutton, Michael;
- Szekeres, Phillip
Publication type:
Abstract
Dramatic increases in phosphorylation of tau only on specific epitopes correlates with decline in motor function in aged P301S mice
Published in:
2010
By:
- Szekeres, Philip G.;
- Glover, Sarah J.;
- Lakics, Viktor;
- Cella, Claire V.;
- Purcell, Robert;
- Murray, Tracey K.;
- Cavallini, Annalisa;
- Lavenir, Isabelle;
- Goedert, Michel;
- Davies, Peter;
- Hutton, Michael L.;
- O'Neill, Michael J.
Publication type:
Abstract
Investigation of GSK-3 alpha and GSK-3 beta phosphorylation of tau in primary neuronal cultures and neuroblastoma cells
Published in:
2010
By:
- Bose, Suchira;
- Cavallini, Annalisa;
- Glover, Sarah;
- Bell, Amanda;
- Sargent, Samantha;
- Angers, Rachel;
- Lakics, Viktor;
- Davies, Peter;
- Hutton, Michael;
- Szekeres, Philip
Publication type:
Abstract
Synaptic alterations associated with disrupted sensory encoding in a mouse model of tauopathy.
Published in:
Brain Communications, 2024, v. 6, n. 3, p. 1, doi. 10.1093/braincomms/fcae134
By:
- Meftah, Soraya;
- Cavallini, Annalisa;
- Murray, Tracey K;
- Jankowski, Lukasz;
- Bose, Suchira;
- Ashby, Michael C;
- Brown, Jonathan T;
- Witton, Jonathan
Publication type:
Article
Development of P301S tau seeded organotypic hippocampal slice cultures to study potential therapeutics.
Published in:
Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-89230-3
By:
- McCarthy, James M.;
- Virdee, Jasmeet;
- Brown, Jessica;
- Ursu, Daniel;
- Ahmed, Zeshan;
- Cavallini, Annalisa;
- Nuthall, Hugh N.
Publication type:
Article
Determination of amphetamines in human urine by liquid chromatography with fluorimetric detection using a solid-phase extraction procedure.
Published in:
Journal of Separation Science, 2006, v. 29, n. 15, p. 2322, doi. 10.1002/jssc.200600139
By:
- Francesca Bugamelli;
- Roberto Mandrioli;
- Annalisa Cavallini;
- Cesare Baccini;
- Matteo Conti
Publication type:
Article
A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity.
Published in:
Acta Neuropathologica, 2014, v. 127, n. 5, p. 667, doi. 10.1007/s00401-014-1254-6
By:
- Ahmed, Zeshan;
- Cooper, Jane;
- Murray, Tracey;
- Garn, Katya;
- McNaughton, Emily;
- Clarke, Hannah;
- Parhizkar, Samira;
- Ward, Mark;
- Cavallini, Annalisa;
- Jackson, Samuel;
- Bose, Suchira;
- Clavaguera, Florence;
- Tolnay, Markus;
- Lavenir, Isabelle;
- Goedert, Michel;
- Hutton, Michael;
- O'Neill, Michael
Publication type:
Article
Genome-wide RNAseq study of the molecular mechanisms underlying microglia activation in response to pathological tau perturbation in the rTg4510 tau transgenic animal model.
Published in:
Molecular Neurodegeneration, 2018, v. 13, n. 1, p. N.PAG, doi. 10.1186/s13024-018-0296-y
By:
- Wang, Hong;
- Li, Yupeng;
- Ryder, John W.;
- Hole, Justin T.;
- Ebert, Philip J.;
- Airey, David C.;
- Qian, Hui-Rong;
- Logsdon, Benjamin;
- Fisher, Alice;
- Ahmed, Zeshan;
- Murray, Tracey K.;
- Cavallini, Annalisa;
- Bose, Suchira;
- Eastwood, Brian J.;
- Collier, David A.;
- Dage, Jeffrey L.;
- Miller, Bradley B.;
- Merchant, Kalpana M.;
- O'Neill, Michael J.;
- Demattos, Ronald B.
Publication type:
Article
Short Fibrils Constitute the Major Species of Seed-Competent Tau in the Brains of Mice Transgenic for Human P301S Tau.
Published in:
Journal of Neuroscience, 2016, v. 36, n. 3, p. 762, doi. 10.1523/JNEUROSCI.3542-15.2016
By:
- Jackson, Samuel J.;
- Kerridge, Caroline;
- Cooper, Jane;
- Cavallini, Annalisa;
- Falcon, Benjamin;
- Cella, Claire V.;
- Landi, Alessia;
- Szekeres, Philip G.;
- Murray, Tracey K.;
- Ahmed, Zeshan;
- Goedert, Michel;
- Hutton, Michael;
- O'Neill, Michael J.;
- Bose, Suchira
Publication type:
Article

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