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- Title
Ketone Body Infusion Abrogates Growth Hormone-Induced Lipolysis and Insulin Resistance.
- Authors
Lyng Høgild, Morten; Hjelholt, Astrid Johannesson; Hansen, Jakob; Pedersen, Steen Bønløkke; Møller, Niels; Wojtaszewski, Jørgen F. P.; Johannsen, Mogens; Jessen, Niels; Jørgensen, Jens Otto Lunde
- Abstract
Context: Exogenous ketone body administration lowers circulating glucose levels but the underlying mechanisms are uncertain. Objective: We tested the hypothesis that administration of the ketone body ß-hydroxybutyrate (ßOHB) acutely increases insulin sensitivity via feedback suppression of circulating free fatty acid (FFA) levels. Methods: In a randomized, single-blinded crossover design, 8 healthy men were studied twice with a growth hormone (GH) infusion to induce lipolysis in combination with infusion of either ßOHB or saline. Each study day comprised a basal period and a hyperinsulinemic-euglycemic clamp combined with a glucose tracer and adipose tissue and skeletal muscle biopsies. Results: ßOHB administration profoundly suppressed FFA levels concomitantly with a significant increase in glucose disposal and energy expenditure. This was accompanied by a many-fold increase in skeletal muscle content of both ßOHB and its derivative acetoacetate. Conclusion: Our data unravel an insulin-sensitizing effect of ßOHB, which we suggest is mediated by concomitant suppression of lipolysis.
- Subjects
KETONE body metabolism; SOMATOTROPIN; LIPOLYSIS
- Publication
Journal of Clinical Endocrinology & Metabolism, 2023, Vol 108, Issue 3, p653
- ISSN
0021-972X
- Publication type
Article
- DOI
10.1210/clinem/dgac595