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- Title
Two-Dimensional Speckle Tracking Echocardiography Detects Subclinical Left Ventricular Systolic Dysfunction among Adult Survivors of Childhood, Adolescent, and Young Adult Cancer.
- Authors
Yu, Anthony F.; Raikhelkar, Jayant; Zabor, Emily C.; Tonorezos, Emily S.; Moskowitz, Chaya S.; Adsuar, Roberto; Mara, Elton; Huie, Kevin; Oeffinger, Kevin C.; Steingart, Richard M.; Liu, Jennifer E.
- Abstract
Two-dimensional speckle tracking echocardiography (2DSTE) provides a sensitive measure of left ventricular (LV) systolic function and may aid in the diagnosis of cardiotoxicity. 2DSTE was performed in a cross-sectional study of 134 patients (mean age: 31.4±8.8 years; 55% male; mean time since diagnosis: 15.4±9.4 years) previously treated with anthracyclines (mean cumulative dose: 320±124 mg/m2), with (n=52) or without (n=82) mediastinal radiotherapy. The prevalence of LV systolic dysfunction, defined as fractional shortening < 27%, LV ejection fraction (LVEF) < 55%, and global longitudinal strain (GLS) ≤ 16%, was 5.2%, 6.0%, and 23.1%, respectively. Abnormal GLS was observed in 24 (18%) patients despite a normal LVEF. Indices of LV systolic function were similar regardless of anthracycline dose. However, GLS was worse (18.0 versus 19.0, p=0.003) and prevalence of abnormal GLS was higher (36.5% versus 14.6%, p=0.004) in patients treated with mediastinal radiotherapy. Mediastinal radiotherapy was associated with reduced GLS (p=0.040) after adjusting for sex, age, and cumulative anthracycline dose. In adult survivors of childhood, adolescent, and young adult cancer, 2DSTE frequently detects LV systolic dysfunction despite a normal LVEF and may be useful for the long-term cardiac surveillance of adult cancer survivors.
- Subjects
LEFT heart ventricle; HEART ventricle diseases; AGE distribution; ANTHRACYCLINES; BLOOD pressure; CANCER patients; CARDIOTOXICITY; ECHOCARDIOGRAPHY; MEDIASTINUM; PROBABILITY theory; RADIOTHERAPY; TUMORS; TUMORS in children; CROSS-sectional method; DESCRIPTIVE statistics; VENTRICULAR ejection fraction; DISEASE complications; DIAGNOSIS
- Publication
BioMed Research International, 2016, Vol 2016, p1
- ISSN
2314-6133
- Publication type
Article
- DOI
10.1155/2016/9363951