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- Title
Effect of keishibukuryogan combined with tocopherol nicotinate on sperm parameters in patients with a varicocele.
- Authors
Takeshima, Teppei; Karibe, Jurii; Saito, Tomoki; Ishibashi, Yukari; Usui, Kimitsugu; Mori, Kohei; Kuroda, Shinnosuke; Komeya, Mitsuru; Yumura, Yasushi
- Abstract
Objective: To evaluate the efficacy of keishibukuryogan, a traditional Kampo formula known to be an anti‐Oketsu (impaired microcirculation and non‐physiological blood congestion) drug, in combination with an anti‐oxidant for the treatment of varicoceles. Methods: We retrospectively analyzed 119 patients with palpable and subclinical varicoceles who were treated with 7.5 g/day of keishibukuryogan and 600 mg/day of tocopherol nicotinate. Their motile sperm concentrations at the start of medication and after 3 months were compared. As a subgroup analysis, a comparison test was carried out between patients with a high‐grade varicocele and those with a low‐grade varicocele. Results: The mean age of the study patients was 35.6 years. Among them, 17, 41, 44 and 17 had subclinical, grade 1, grade 2 and grade 3 varicoceles, respectively. Overall, the differences in motile sperm concentration (millions/mL) before and after treatment were not significant (median 0.58, 95% confidence interval −0.12 to 1.56; P = 0.115). The results of the subgroup analysis showed that the motile sperm concentration in patients with a low‐grade varicocele significantly increased (median 1.21, 95% confidence interval 0.45–2.47; P = 0.024); however, no significant improvements were seen in patients with a high‐grade varicocele. Conclusions: The results of the present study showed that the combination of keishibukuryogan and an anti‐oxidant had a limited effect on varicoceles, but they suggest that it is effective for the treatment of low‐grade varicoceles.
- Subjects
VARICOCELE; VITAMIN E; JAPANESE herbal medicine; SPERMATOZOA; CONFIDENCE intervals
- Publication
International Journal of Urology, 2022, Vol 29, Issue 2, p165
- ISSN
0919-8172
- Publication type
Article
- DOI
10.1111/iju.14746