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- Title
CD1d and CD1d-restricted iNKT-cells play a pivotal role in contact hypersensitivity.
- Authors
Nieuwenhuis, Edward E. S.; Gillessen, Silke; Scheper, Rik J.; Exley, Mark A.; Taniguchi, Masaru; Balk, Steven P.; Strominger, Jack L.; Dranoff, Glenn; Blumberg, Richard S.; Wilson, S. Brian
- Abstract
Nieuwenhuis EES, Gillessen S, Scheper RJ, Exley MA, Taniguchi M, Balk SP, Strominger JL, Dranoff G, Blumberg RS, Wilson SB. CD1d and CD1d-restricted iNKT-cells play a pivotal role in contact hypersensitivity.CD1d-restricted T-cells are activated by glycolipids presented by the major histocompatibility complex class-Ib molecule CD1d, found on the surface of antigen-presenting cells (APC). This interaction between APC, most notably dendritic cells (DC), and CD1d-restricted T-cells is an important regulatory step in the initiation of adaptive immune responses. It is well known that DC play a crucial role in the induction of contact hypersensitivity (CHS), a frequently studied form ofin vivoT-cell-mediated immunity. In this study, we show that CD1d-restricted T-cells are also necessary for CHS, because both wild-type mice treated systemically or topically with CD1d glycolipid antagonists and CD1d-restricted T-cell-null mice have markedly diminished CHS responses. Thus, pharmacologic antagonists of CD1d can be used as effective inhibitors of CHS, a prototype for a variety of delayed-type tissue hypersensitivity responses.
- Subjects
CELLS; MAJOR histocompatibility complex; HLA histocompatibility antigens; DENDRITIC cells; IMMUNE response; LYMPHOID tissue
- Publication
Experimental Dermatology, 2005, Vol 14, Issue 4, p250
- ISSN
0906-6705
- Publication type
Article
- DOI
10.1111/j.0906-6705.2005.00289.x