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- Title
Simple non-invasive prenatal detection of Hb Bart's disease by analysis of fetal erythrocytes in maternal blood.
- Authors
Lau, Elizabeth T.; Kwok, Yvonne K.; Luo, Hong Yuan; Leung, K. Y.; Lee, C. P.; Lam, Y. H.; Chui, David H. K.; Tang, Mary H. Y.
- Abstract
Objective To investigate a simple non-invasive technique for early detection of Hemoglobin (Hb) Bart's disease. Method Maternal blood smears from 8 known Hb Bart's pregnancies and 40 at-risk pregnancies were investigated. Maternal peripheral blood smears were stained with fluorescence-labeled monoclonal antibodies against α- and embryonic ζ-globin chains. Results Fetal nonnucleated red blood cells, stained with anti-ζ but not with anti-α globin antibodies were found in 15 out of 16 affected pregnancies but were not detected in 23 out of 24 unaffected pregnancies. Conclusion Results showed that non-invasive immunofluorescence staining of maternal blood is a feasible approach for screening Hb Bart's disease before ultrasound manifestation in affected pregnancies. Copyright © 2005 John Wiley & Sons, Ltd.
- Publication
Prenatal Diagnosis, 2005, Vol 25, Issue 2, p123
- ISSN
0197-3851
- Publication type
Article
- DOI
10.1002/pd.1096