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- Title
The efficacy of radio-frequency ablation for metastatic lung or liver tumors of male germ cell tumors as an alternative minimally invasive therapy after salvage chemotherapy.
- Authors
Naya, Yoshio; Nakamura, Terukazu; Oishi, Masakatsu; Ueda, Takashi; Nakanishi, Hiroyuki; Naitoh, Yasuyuki; Hongo, Fumiya; Kamoi, Kazumi; Okihara, Koji; Tanaka, Osamu; Yamagami, Takuji; Yamada, Kei; Miki, Tsuneharu
- Abstract
Background: The aim of this study was to assess the efficacy of radio-frequency ablation (RFA) for metastatic lung or liver tumors of germ cell tumors (GCTs) after chemotherapy. Methods: RFA with computed tomography guidance and monitoring was performed in 24 patients with 48 metastatic lung or liver tumors of GCTs. Group A consisted of 9 patients with tumor marker normalization after salvage chemotherapy and group B consisted of 15 patients without tumor marker normalization in spite ofintensive treatment. Results: Out of 48 tumors, 41 tumors in 21 patients were evaluated for the efficacy of the RFA treatment. Of the 41 tumors, successful ablation was achieved in 34 (82.9 %). The patients in group A had significantly better survival than the patients in group B ( p = 0.0003). In group A, all 9 patients are still alive with no evidence of disease (NED). Patients with a solitary tumor had significantly better survival than those with multiple tumors ( p = 0.0247). In group B, 2 patients are alive with NED, 1 patient is alive with disease, and the remaining 12 patients have died a tumor-related death. Three cases of pneumothorax requiring intubation were observed. Conclusions: RFA is less invasive than surgery and is an effective treatment option for curative and palliative therapy as an alternative to invasive salvage surgery for post-chemotherapeutic metastatic lung or liver lesions from GCT.
- Subjects
LIVER tumors; TUMOR treatment; GERM cell tumors; CANCER chemotherapy; SALVAGE therapy; ABLATION techniques; COMPUTED tomography
- Publication
International Journal of Clinical Oncology, 2015, Vol 20, Issue 6, p1192
- ISSN
1341-9625
- Publication type
Article
- DOI
10.1007/s10147-015-0824-5