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- Title
Incidence and Prognosis of Colorectal Cancer After Heart Transplantation: Data From the Spanish Post-Heart Transplant Tumor Registry.
- Authors
Sagastagoitia-Fornie, Marta; Morán-Fernández, Laura; Blázquez-Bermejo, Zorba; Díaz-Molina, Beatriz; Gómez-Bueno, Manuel; Almenar-Bonet, Luis; López-Granados, Amador; González-Vílchez, Francisco; Mirabet-Pérez, Sonia; García-Romero, Elena; Jose M., Sobrino-Márquez; Rábago Juan-Aracil, Gregorio; Angels Castel-Lavilla, Maria; Blasco-Peiro, Teresa; Garrido-Bravo, Iris; De La Fuente-Galán, Luis; Muñiz, Javier; Crespo-Leiro, María G.
- Abstract
In this observational and multicenter study, that included all patients who underwent a heart transplantation (HT) in Spain from 1984 to 2018, we analyzed the incidence, management, and prognosis of colorectal cancer (CRC) after HT. Of 6,244 patients with a HT and a median follow-up of 8.8 years since the procedure, 116 CRC cases (11.5% of noncutaneous solid cancers other than lymphoma registered) were diagnosed, mainly adenocarcinomas, after a mean of 9.3 years post-HT. The incidence of CRC increased with age at HT from 56.6 per 100,000 person-years among under 45 year olds to 436.4 per 100,000 person-years among over 64 year olds. The incidence rates for ageat-diagnosis groups were significantly greater than those estimated for the general Spanish population. Curative surgery, performed for 62 of 74 operable tumors, increased the probability of patient survival since a diagnosis of CRC, from 31.6% to 75.7% at 2 years, and from 15.8% to 48.6% at 5 years, compared to patients with inoperable tumors. Our results suggest that the incidence of CRC among HT patients is greater than in the general population, increasing with age at HT.
- Subjects
SPAIN; HEART transplantation; COLORECTAL cancer; CANCER prognosis; TRANSPLANTATION of organs, tissues, etc.; OVERALL survival; HEART tumors; HEREDITARY nonpolyposis colorectal cancer
- Publication
Transplant International, 2023, p1
- ISSN
0934-0874
- Publication type
Article
- DOI
10.3389/ti.2023.11042