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- Title
Androgen deprivation therapy caused a drastic proliferation of B-cell lymphoma with IgG4-related disease in patients with prostate cancer: a case report.
- Authors
Sasagawa, Hajime; Numakura, Kazuyuki; Mori, Mizuki; Kobayashi, Mizuki; Kashima, Soki; Yamamoto, Ryohei; Nara, Taketoshi; Saito, Mitsuru; Narita, Shintaro; Nanjo, Hiroshi; Habuchi, Tomonori
- Abstract
Background: We report a case of diffuse large B-cell lymphoma that progressed rapidly after androgen deprivation therapy for prostate cancer in a patient with a history of IgG4-related disease. Estrogen has been reported to be a possible cause of acute exacerbations of malignant lymphoma only in mouse models. Therefore, its clinical significance has not been clarified. Case presentation: This case report describes a 75-year-old man with prostate cancer who had IgG4-related disease. Hormone therapy was initiated to treat prostate cancer, but he developed dyspnea and back pain. A diagnosis was made of diffuse large B-cell lymphoma. Immunohistochemistry was positive for estrogen receptor β, which led us to suspect rapid progression of diffuse large B-cell lymphoma due to estrogen suppression by gonadotropin-releasing hormone antagonists. Hormone therapy was discontinued, and the patient received R-CHOP therapy. Subsequently, the lymphoma masses shrunk, and the patient obtained remission. Conclusion: This case is the first report of clinical significance regarding the crucial role of estrogen and estrogen receptor β in malignant lymphoma in a patient with IgG4-related disease. Our report aims to raise awareness of the need to carefully select treatment options for prostate cancer patients with IgG4-related disease or lymphoma.
- Subjects
PROSTATE cancer; ANDROGEN deprivation therapy; DIFFUSE large B-cell lymphomas; PROSTATE cancer patients; LYMPHOMAS; PROSTATE diseases
- Publication
Journal of Cancer Research & Clinical Oncology, 2023, Vol 149, Issue 16, p15091
- ISSN
0171-5216
- Publication type
Article
- DOI
10.1007/s00432-023-05292-y