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- Title
Linezolid pharmacokinetics and pharmacodynamics in clinical treatment.
- Authors
Dryden, Matthew S.
- Abstract
Linezolid has been widely used in the treatment of Gram-positive infections for more than a decade. It is unique amongst antibiotics active against most multiply-resistant Gram-positive bacteria in that there is an oral preparation with 100% bioavailability and an extensive volume of distribution. This review examines pharmacokinetic data relating to linezolid use in different patient groups (obesity, enteral feeding, renal failure, neonates, and paediatrics) and in different clinical conditions (sepsis syndrome, skin and soft tissue infection, diabetic foot infection, pneumonia, bone and joint infection, infection of the central nervous system, eye infection, and neutropenic sepsis).
- Subjects
ANTIBIOTICS; GRAM-positive bacterial infections; PHARMACOKINETICS; BIOAVAILABILITY; ACUTE kidney failure
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 2011, Vol 66, piv7
- ISSN
0305-7453
- Publication type
Article
- DOI
10.1093/jac/dkr072