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- Title
In vitro analyses of the effect of aromatic diamidines upon Trypanosoma cruzi.
- Authors
Daliry, Anissa; Silva, Patrícia B. Da; Da Silva, Cristiane F.; Batista, Marcos Meuser; De Castro, Solange L.; Tidwell, Richard R.; Soeiro, Maria de Nazaré C.
- Abstract
Objectives: Aromatic diamidines (ADs) have been recognized as promising antiparasitic agents. Therefore, in the present work, the in vitro trypanocidal effect of 11 ADs upon the relevant clinical forms of Trypanosoma cruzi was evaluated, as well as determining their toxicity to mammalian cells and their subcellular localization.
- Subjects
AMIDINES; ANTIPARASITIC agents; TRYPANOSOMA cruzi; TOXICOLOGY; MAMMAL physiology; CYTOLOGICAL research; THERAPEUTICS
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 2009, Vol 64, Issue 4, p747
- ISSN
0305-7453
- Publication type
Article
- DOI
10.1093/jac/dkp290