We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Production of the secondary metabolites ϒ-aminobutyric acid and monacolin K by Monascus.
- Authors
Yuan-Chi Su; Jyh-Jye Wang; Tzu-Tsen Lin; Tzu-Ming Pan
- Abstract
γ-Aminobutyric acid (GABA), a hypotensive agent, and monacolin K, a cholesterol-lowering drug, can be produced by Monascus spp. Under optimal culture conditions, the products of fermentation using Monascus spp. may serve as a multi-functional dietary supplement and can prevent heart disease. In this study, Monascus purpureus CCRC 31615, the strain with the highest amount of monacolin K, was identified from 16 strains using solid fermentation. Its GABA productivity was particularly high. Addition of sodium nitrate during solidstate fermentation of M. purpureus CCRC 31615 improved the productivity of monacolin K and GABA to 378 mg/kg and 1,267.6 mg/kg, respectively. GABA productivity increased further to 1,493.6 mg/kg when dipotassium hydrophosphate was added to the medium.
- Subjects
MICROBIAL biotechnology; GABA; METABOLITES; MONASCUS
- Publication
Journal of Industrial Microbiology & Biotechnology, 2003, Vol 30, Issue 1, p41
- ISSN
1367-5435
- Publication type
Article
- DOI
10.1007/s10295-002-0001-5