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- Title
!金针菇源维生素D2复合片剂对去卵巢 骨质疏松大鼠血清生化指标、骨及脏器影响.
- Authors
胡代花; 杨旭; 陈旺; 冯自立; 张嘉昕; 李翠丽; 隋香菊; 祁珊珊; 雒志恒
- Abstract
The effect of Flammulina velutiper-derived vitamin D2(VD2)compound tablets on the serum biochemical indexes, bones, and organs of ovariectomized rats was investigated. The rat osteoporosis model was established by removing the ovaries. Healthy female sprague -dawley rats were divided into the sham -operated (Sham), ovariectomized(OVX), OVX + commercial VD2(OVX +VD2), and OVX + F. velutiper VD2 compound tablet(OVX + MVHP)groups. The rats were treated every other day for 16 weeks. Afterward, their sera, tibias, femurs, and organs were collected. The serum calcium, phosphorus, alkaline phosphatase(AKP), and tartrate resistant acid phosphatase(StrACP)levels were determined. The organs were weighed, and the organ indexes were calculated. Additionally, bone and uterine tissue sections were prepared and stained with hematoxylin and eosin, and tissue structures were observed using a pathological image analysis system. Compared with that in the OVX group, the serum calcium concentration in the OVX + MVHP group was significantly higher(p<0.05),while the AKP concentration was significantly lower(p<0.05). In contrast, there was no significant difference in the serum phosphorus and StrACP concentrations(p>0.05). The heart, liver, kidney and uterus serum biochemical indexes were significantly different(p<0.05), while the spleen serum biochemical index was not(p>0.05). Additionally, the uterus tube and the lining of the uterus were significantly thicker (p<0.05), and there was a significant reduction in the thickness of the uterus (p<0.05). The femur and tibia were dense, and the beam spacing as well as the bone marrow cavity were smaller. Altogether, these results indicated that F. velutiperderived VD2 compound tablets might prevent the occurrence of postmenopausal osteoporosis.
- Subjects
ACID phosphatase; ERGOCALCIFEROL; OSTEOPOROSIS in women; ALKALINE phosphatase; IMAGE analysis; ORGANS (Anatomy)
- Publication
Food Research & Development, 2021, Vol 42, Issue 10, p24
- ISSN
1005-6521
- Publication type
Article
- DOI
10.12161/j.issn.1005-6521.2021.10.004