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- Title
How to interpret randomised trials of test-treatment combinations: a critical evaluation of research on uterine Doppler test to predict, and aspirin to prevent, pre-eclampsia.
- Authors
Fox C; Khan KS; Coomarasamy A; Fox, C; Khan, K S; Coomarasamy, A
- Abstract
The methodology to evaluate either a test or treatment is well developed and understood. However, the design, conduct and interpretation of a combination of a test and a treatment in a single study are fraught with complexities. There are two distinct study designs to evaluate test-treatment combinations, with randomisation occurring either before or after the test. We present critical issues that need to be considered when evaluating and appraising test-treatment combinations, using the example of research on the uterine artery Doppler test to predict, and aspirin to prevent, pre-eclampsia.
- Publication
BJOG: An International Journal of Obstetrics & Gynaecology, 2010, Vol 117, Issue 7, p801
- ISSN
1470-0328
- Publication type
journal article
- DOI
10.1111/j.1471-0528.2010.02577.x