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- Title
Effect of Ipratropium Inhalation on Pupil Dilatation in Rats.
- Authors
Akça, Hatice Şeyma; İhtiyar, Büşra; Kokulu, Kamil; Algın, Abdullah; Özdemir, Serdar; Eroğlu, Serkan Emre; Aksel, Gökhan
- Abstract
Aim: This study aimed to investigate the effect of inhaled ipratropium on pupil diameter when applied directly to the eye in a closed environment. Materials and Methods: A total of 14, 8-week-old and 350-g weight Sprague-Dawley rats were obtained from Yeditepe University Laboratory of Experimental Animals for research. At constant temperature (22 °C±3 °C) and 12-hour light/dark cycle, the rats had access to standard food and water. A total of 7 rats were exposed to ipratropium, whereas 7 rats were given saline nebular. Pupil diameters and pupillary-orbital diameter ratios were compared before and 2 hours after drug exposure. Pupil diameters and pupillary-orbital diameter ratios measured before and 2 hours after ipratropium inhalation were compared in the computer environment after 4288 × 2848 pixel magnification. Results: No significant difference was observed in the pupil/orbital diameter ratios in either right or left eyes after treatment compared to baseline values (p>0.05, for both). No significant difference was found in Delta rates. The numerical data fitted the normal distribution. Conclusion: In our study, no significant difference was determined in diameter changes that would advocate a more careful action in the case of anisocoria development in patients receiving ipropropium treatment and perform a detailed neurological examination and request neurology consultation as soon as possible. Anisocoria or changes in pupil diameters encountered in both pupils may not always be associated with drug use.
- Subjects
DRUG utilization; RATS; GAUSSIAN distribution; LABORATORY animals; FOOD standards
- Publication
Eurasian Journal of Emergency Medicine, 2021, Vol 20, Issue 1, p39
- ISSN
2149-5807
- Publication type
Article
- DOI
10.4274/eajem.galenos.2020.29494