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- Title
Relationship of Hypertension and Systolic Blood Pressure With the Risk of Stroke or Bleeding in Patients With Atrial Fibrillation: The Fushimi AF Registry.
- Authors
Mitsuru Ishii; Hisashi Ogawa; Takashi Unoki; Yoshimori An; Moritake Iguchi; Nobutoyo Masunaga; Masahiro Esato; Yeong-Hwa Chun; Hikari Tsuji; Hiromichi Wada; Koji Hasegawa; Mitsuru Abe; Masaharu Akao
- Abstract
BACKGROUND Hypertension is considered a major risk factor of stroke and systemic embolism (SE) as well as bleeding in patients with atrial fibrillation (AF). The purpose of this study was to investigate the relationship of hypertension and systolic blood pressure (SBP) with the risk of stroke/SE or bleeding in AF patients. METHODS The Fushimi AF Registry, a community-based prospective survey, was designed to enroll all of the AF patients in Fushimi-ku, Kyoto. Fushimi-ku is densely populated with a total population of 283,000. Follow-up data were available for 3,713 patients (follow-up rate 90.0%) as of August 2015, and the median follow-up period was 1,035 days. RESULTS We compared the clinical backgrounds at baseline, and follow-up outcomes of AF patients between those with hypertension (HTN; n = 2,304, 62.1% of total) and those without (non-HTN; n = 1,409). History of hypertension was neither associated with the incidence of stroke/SE, ischemic stroke, hemorrhagic stroke nor major bleeding. However, when we divided the HTN group by baseline SBP ≥150 mm Hg (HTN-high blood pressure [HBP]: n = 305, 13.3% of HTN group) or <150 mm Hg (HTN-low blood pressure [LBP]: n = 1,983), HTN-HBP group was significantly associated with a higher incidence of both stroke/SE (hazard ratio [HR]: 1.74, 95% confidence interval [CI]: 1.08-- 2.72) and major bleeding (HR: 2.01, 95% CI: 1.21--3.23) compared with the non-HTN group. In contrast, HTN-LBP group was not associated with the risk of stroke/SE or major bleeding, compared with the non- HTN group. CONCLUSION The incidences of stroke/SE and bleeding were higher in AF and hypertension patients with elevated SBP. UMIN Clinical Trials Registry: UMIN000005834
- Subjects
HYPERTENSION; ATRIAL fibrillation; EMBOLISMS; STROKE; MULTI-infarct dementia
- Publication
American Journal of Hypertension, 2017, Vol 30, Issue 11, p1073
- ISSN
0895-7061
- Publication type
Article
- DOI
10.1093/ajh/hpx094