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- Title
Effect of acupuncture on hippocampal Ref-1 expression in cerebral multi-infarction rats.
- Authors
Liu, Cun-Zhi; Li, Zu-Guang; Wang, De-Jin; Shi, Guang-Xia; Liu, Li-Ying; Li, Qian-Qian; Li, Chong
- Abstract
Redox effector factor (Ref-1) is a sensitive marker for oxidative cellular injury. The aim of this study was to investigate the effects of acupuncture on hippocampal Ref-1 expression in cerebral multi-infarction rats. The rats with reference memory impairment were randomly allocated to three groups: impaired group, acupuncture group and placebo acupuncture group. Moreover, normal group and sham-operated group were set as control groups. Morris water maze test showed that cerebral multi-infarction rats did not present significant changes in spatial working memory performance. Further investigation by immunohistochemistry revealed that acupunctural treatment significantly increased the expression of Ref-1 in the hippocampus of the impaired rats. These findings suggested that the spatial working memory was unaffected in the cerebral multi-infarction rats although spatial reference memory deficits were detected in our previous study; in addition, acupuncture could increase the Ref-1 expression, consequently exerting the anti-oxidant effects.
- Subjects
ACUPUNCTURE; HIPPOCAMPUS (Brain); GENE expression; BIOMARKERS; SHORT-term memory; CEREBRAL infarction; LABORATORY rats
- Publication
Neurological Sciences, 2013, Vol 34, Issue 3, p305
- ISSN
1590-1874
- Publication type
Article
- DOI
10.1007/s10072-012-0994-0