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- Title
Relatively Benign Clinical Course in Asymptomatic Patients with Brugada-Type Electrocardiogram Without Family History of Sudden Death.
- Authors
Takenaka, Shiho; Kusano, Kengo Fukushima; Hisamatsu, Kenichi; Nagase, Satoshi; Nakamura, Kazufumi; Morita, Hiroshi; Matsubara, Hiromi; Emori, Tetsuro; Ohe, Tohru
- Abstract
Introduction: The incidence of sudden death or ventricular fibrillation (VF) in asymptomatic Brugada syndrome patients with a family history of sudden death is reported to be very high. However, there are few reports on the prognosis of asymptomatic Brugada syndrome patients without a family history of sudden death. Methods and Results: Eleven patients (all male; mean age 40.5 ± 9.6 years, range 26 to 56) with asymptomatic Brugada-type ECG who had no family history of sudden death were evaluated. The degrees of ST segment elevation and conduction delay on signal-averaged ECG (SAECG) before and after pilsicainide were evaluated in all 11 patients. VE inducibility by ventricular electrical stimulation also was evaluated in 8 of 11 patients. Patients were followed for a period of 9 to 84 months (mean 42.5 ± 21.6). The J point level was increased (V1: 0.19 ± 0.09 mV to 0.36 ± 0.23 mV; V2: 0.31 ± 0.12 mV to 0.67 ± 0.35 mV) by pilsicainide. Conduction delay was increased (total QRS: 112.2 ± 6.3 msec to 131.7 ± 6.3 msec; under 40 µV: 42.0 ± 8.5 msec to 52.7 ± 12.7 msec; last 40 msec: 17.4 ± 5.9 µV to 10.4 ± 6.1 µV) on SAECG by pilsicainide. VF was induced in only 1 of 8 patients. None of the patients had syncope or sudden death during a mean follow-up of 42.5 ± 21.6 months. Conclusion: This study suggests that asymptomatic patients with Brugada-type ECG who have no family history of sudden death have a relatively benign clinical course.
- Subjects
BRUGADA syndrome; SUDDEN death; VENTRICULAR fibrillation; ELECTROCARDIOGRAPHY; RESEARCH
- Publication
Journal of Cardiovascular Electrophysiology, 2001, Vol 12, Issue 1, p2
- ISSN
1045-3873
- Publication type
Article
- DOI
10.1046/j.1540-8167.2001.00002.x