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- Title
O POTENCIAL TERAPÊUTICO NEUROLÓGICO DOS COMPONENTE DA Cannabis sativa.
- Authors
FERNANDA SAMPAIO, MARIA; CORREIA AZEVEDO, PEDRO HENRIQUE; FRANCISCO LUCENA, PEDRO; SOARES PORTO, PEDRO; DECAT GONÇALVES, VICTOR; BAPTISTA, VINICIUS; VALENTE ROCHA, LAMARA LAGUARDIA
- Abstract
INTRODUCTION: Cannabis sativa is essentially composed of two substances: tetrahydrocannabidiol (THC) and cannabidiol (CBD) and its use as a medicine has been studied since the twentieth century. However, its social stigma makes it a controversial topic. OBJECTIVES: o review articles addressing the use of Cannabis sativa and its components in the treatment of neurological disorders (Depression, Alzheimer, Epilepsy and Chronic Pain), discussing its mechanism of treatment, action, its therapeutic potential and future perspectives analyzing its effectiveness in different studies. METHODS: Integrative literary review of articles from the SciELO and PubMed databases, using the keywords "canabidiol", "THC" and "neurological disorders". We analyzed articles published between 1990 and 2020, in English and Portuguese. RESULTS: Studies have shown that the components of Cannabis sativa have high therapeutic potential in the mentioned neurological diseases, since their administration decreases the intensity of symptoms at animal, cellular and human levels. CONCLUSION: The therapeutic profile of cannabinoids has been clarified. describing their mechanisms of action along with their time-effect, restriction by regulatory agencies, their administered doses and their possible side effects. Therefore, it was found that these compounds promote anxiolytic and euphoric effects, analgesia, anticonvulsant and anti-apoptotic actions, being beneficial for neurological diseases. However, complete studies are still needed, mainly about the chemical profiles, dosages and side effects of the use of these substances and their disassociation with the recreational form of Cannabis sativa to become medicines in Brazil.
- Publication
Brazilian Journal of Surgery & Clinical Research, 2021, Vol 34, Issue 1, p52
- ISSN
2317-4404
- Publication type
Article