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- Title
Senile EBV-associated B-cell lymphoproliferative disorder of indolent clinical phenotype with recurrence as aggressive lymphoma.
- Authors
Shiozawa, Eisuke; Saito, Bungo; Yamochi-Onizuka, Toshiko; Makino, Reiko; Takimoto, Masafumi; Nakamaki, Tsuyoshi; Tomoyasu, Shigeru; Ota, Hidekazu
- Abstract
Senile EBV-associated B-cell lymphoproliferative disorder (LPD) was proposed as a new disease entity in 2003. This condition has a high incidence in elderly people without underlying immunodeficiencies, and is characterized by EBV-positive B-cell proliferation with a polymorphic composition. Histologically, the disease has two subtypes. The polymorphic LPD (PLPD) subtype has a preferable prognosis, whereas the large cell lymphoma (LCL) subtype involves aggressive disease progression. Reported herein is a case of senile EBV-BLPD with indolent clinical features and PLPD subtype in the initial phase that recurred as an aggressive lymphoma 3 years after the initial diagnosis. In the recurrent phase, Southern blotting confirmed monoclonal proliferation of large lymphoid B-cells. In both the initial and recurrent phases, polymerase chain reaction (PCR) yielded a single discrete band of a similar size due to an immunoglobulin heavy-chain gene rearrangement, indicating that the large lymphoid B-cells retained identical monoclonality throughout the histological progression and over the whole clinical course. These results suggest that the PLPD subtype is a histological finding in early phase senile EBV-BLPD and that the LCL subtype reflects the progressive phase of the disease.
- Subjects
DISEASES in older people; LYMPHOMAS; POLYMERASE chain reaction; LYMPHATIC disease diagnosis; LYMPHOPROLIFERATIVE disorders; PROGNOSIS
- Publication
Pathology International, 2007, Vol 57, Issue 10, p688
- ISSN
1320-5463
- Publication type
Article
- DOI
10.1111/j.1440-1827.2007.02158.x