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- Title
Dinuclear Copper(I) Thiodiacetate Complex-Mediated Expeditious Synthesis of the Chlorine-Containing Cyclen-Cored 36-Glucose-Coated Glycodendrimer.
- Authors
Agrahari, Anand K.; Kumar, Sunil; Sharma, Anindra; Tiwari, Vinod K.
- Abstract
High-sugar-tethered glycodendrimers are a remarkable tool in glycobiology for the investigation of carbohydrate-protein interaction using its multivalency property. An enthralling double-stage convergent synthetic approach was selected to build a novel class of chlorine-containing glucose-coated dendrimers using an efficient click catalyst 'dinuclear copper(I) thiodiacetate complex.' In this context, cyclen core was developed through a divergent approach, while the glucodendron was developed via a convergent approach independently. Both azide-alkyne partners were coupled through a modular copper azide-alkyne cycloaddition (CuAAC) strategy to afford a high yield of the desired 36-glucose-coated glycodendrimer. The synthesized glycodendrimer has been elucidated by NMR, gel permeation chromatography (GPC), and IR spectral analysis.
- Subjects
DENDRIMERS; GEL permeation chromatography; PROTEIN-carbohydrate interactions; COPPER
- Publication
Journal of Chemistry, 2021, p1
- ISSN
2090-9063
- Publication type
Article
- DOI
10.1155/2021/4209514