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- Title
Effect of Propolis on Hepatocellular Carcinoma Cell Proliferation and Fat Deposition.
- Authors
Wenli TIAN; Yazhou ZHAO; Wenjun PENG
- Abstract
[Objective] To preliminarily quantify the control efficacy of human liver cancer by propolis through evaluating the inhibitory effect on HCC cell proliferation and fat deposition. [Methods] The proliferation capacity of propolis-treated hepatoma cells was evaluated by MIT. Oleic acid induction method was adopted to delect the degree of fat deposition in HCC cell. [Results] The content of flavonoids in propolis was determined by HLPC-MS to be (191.472 ± 1.986) mg/g. The tg 9 group (propolis: olive oil = 1:2, V/V) revealed the strongest inhibitory effect on cell proliferation. The triglyceride (TG) contents in all treatment groups were in the range of 410.333 -459.672 nmol/L. [Conclusions] Therefore, propolis can not control fat deposition in cells and the preventative effect of propolis on fatty liver is not satisfactory. However, it has strong inhibitory effect on the proliferation of liver cancer cells.
- Subjects
PROPOLIS; CANCER cell proliferation; LIVER cancer; HEPATOCELLULAR carcinoma; OLEIC acid; FLAVONOIDS; TRIGLYCERIDES; FATTY liver
- Publication
Medicinal Plant, 2013, Vol 4, Issue 8, p54
- ISSN
2152-3924
- Publication type
Article