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- Title
Potential role of adoptively transferred allogeneic WT1-specific CD4<sup>+</sup> and CD8<sup>+</sup> T lymphocytes for the sustained remission of refractory AML.
- Authors
Kim, Y.-J.; Cho, S.-G.; Lee, S.; Kim, M.-S.; Kim, E.-K.; Cho, B.-S.; Sohn, H.-J.; Choi, H. B.; Eom, K.-S.; Min, C.-K.; Kim, H.-J.; Kim, Y.-G.; Kim, D.-W.; Lee, J.-W.; Min, W.-S.; Kim, C.-C.; Kim, T.-G.
- Abstract
The article presents a case study of a 48-year-old man who suffered from myelodysplastic syndrome (MDS) which progressed to acute myeloid leukemia (AML). The disease continued despite induction chemotherapy. He received allogeneic stem cell transplantation (allo-SCT) and no graft-versus-host disease happened but a relapse was observed. It states that graft-versus-leukemia destroy incurable anemia and Wilms' tumor gene (WT1)-specific glycoproteins help in treating hematological malignancies.
- Subjects
MYELODYSPLASTIC syndromes; ACUTE myeloid leukemia; STEM cell transplantation; GRAFT versus host disease; DRUG therapy; GLYCOPROTEINS; ANEMIA
- Publication
Bone Marrow Transplantation, 2010, Vol 45, Issue 3, p597
- ISSN
0268-3369
- Publication type
Case Study
- DOI
10.1038/bmt.2009.191