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- Title
The Effects of a Standardized Extract of Centella asiatica on Postlaser Resurfacing Wound Healing on the Face: A Split-Face, Double-Blind, Randomized, Placebo-Controlled Trial.
- Authors
Damkerngsuntorn, Wilawan; Rerknimitr, Pawinee; Panchaprateep, Ratchathorn; Tangkijngamvong, Natsinee; Kumtornrut, Chanat; Kerr, Stephen J.; Asawanonda, Pravit; Tantisira, Mayuree H.; Khemawoot, Phisit
- Abstract
Background:Centella asiatica, a medicinal plant, has been used traditionally to promote wound healing. Its efficacy on promoting postlaser resurfacing wound healing is lacking. Methods: Thirty individuals with facial acne scars underwent a treatment with 2940 nm Er:YAG laser. Half side of the face was randomized to receive 0.05% w/w ECa 233 gel, a standardized extract of C. asiatica, and the other half a placebo gel. The gels were applied four times daily for 7 days then twice daily for 3 months. Erythema, melanin, and texture index (TI) from Antera3D,® and skin biophysics were obtained at baseline, days 2, 4, and 7, then every 2 weeks for the first month, and every month for 3 months. Three blinded dermatologists assessed the photographs and provided a grading scale of wound appearances. Results: The ECa 233 treated side exhibited significantly less erythema index over total follow-up by 0.03 U (coefficient = −0.03 [95% CI −0.06 to −0.0006]; p = 0.046). In keeping with the physicians' assessment that showed significantly higher improvements in skin erythema at days 2, 4, and 7 (p = 0.009, 0.0061, 0.012), crusting at days 2 (p = 0.02), and general wound appearance at days 2, 4, and 7 (p = 0.008, 0.001, 0.044), TI showed a trend toward better outcome in the ECa 233 group. Skin biophysics did not differ between the two groups. Conclusion: ECa 233 might be an option for postlaser treatment to improve wound appearance.
- Subjects
THAILAND; ACNE; BIOPHYSICS; CONFIDENCE intervals; ERYTHEMA; PHARMACEUTICAL gels; MEDICAL lasers; LONGITUDINAL method; MEDICINAL plants; MELANINS; RESEARCH funding; STATISTICAL sampling; SKIN; WOUND healing; TRAUMATOLOGY diagnosis; PLANT extracts; RANDOMIZED controlled trials; TREATMENT effectiveness; BLIND experiment; DATA analysis software; HYPERPIGMENTATION; MANN Whitney U Test
- Publication
Journal of Alternative & Complementary Medicine, 2020, Vol 26, Issue 6, p529
- ISSN
1075-5535
- Publication type
Article
- DOI
10.1089/acm.2019.0325