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- Title
Maintenance of CD8<sup>+</sup> memory T lymphocytes in the spleen but not in the bone marrow is dependent on proliferation.
- Authors
Siracusa, Francesco; Alp, Özen Sercan; Maschmeyer, Patrick; McGrath, Mairi; Mashreghi, Mir‐Farzin; Hojyo, Shintaro; Chang, Hyun‐Dong; Tokoyoda, Koji; Radbruch, Andreas
- Abstract
It is current belief that numbers of CD8+ memory T lymphocytes in the memory phase of an immune response are maintained by homeostatic proliferation. Here, we compare the proliferation of CD8+ memory T lymphocytes, generated by natural infections and by intentional immunization, in spleen and bone marrow (BM). Fifty percent of CD8+ memory T lymphocytes in the spleen are eliminated by cyclophosphamide within 14 days, indicating that numbers of at least 50% of splenic CD8+ memory T lymphocytes are maintained by proliferation. The numbers of CD8+ memory T lymphocytes in the BM, however, were not affected by cyclophosphamide. This stability was independent of circulating CD8+ memory T cells, blocked by FTY720, showing that BM is a privileged site for the maintenance of memory T lymphocytes, as resident cells, resting in terms of proliferation.
- Publication
European Journal of Immunology, 2017, Vol 47, Issue 11, p1900
- ISSN
0014-2980
- Publication type
Article
- DOI
10.1002/eji.201747063