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- Title
IL-23: One cytokine in control of autoimmunity.
- Authors
Croxford, Andrew L.; Mair, Florian; Becher, Burkhard
- Abstract
During the past decade, it has been firmly established that IL-23 is essential for disease development in several models of autoimmune disease, including psoriatic skin inflammation, inflammatory bowel disease ( IBD), and experimental autoimmune encephalomyelitis ( EAE). The mechanism by which IL-23 exerts its pathogenic role has been mostly scrutinized in the context of Th17 cells, which were thought to mediate autoimmunity by secretion of IL-17 family cytokines. However, the picture emerging now is one of multiple IL-23-responsive cell types, pro-inflammatory cytokine induction, and pathogenic 'licensing' following an IL-23-dominated interaction between the T cell and the antigen-presenting cell ( APC). This review will focus on our changing view of IL-23-dependent autoimmune pathologies with a particular emphasis on the responder cells and their IL-23-induced factors that ultimately mediate tissue destruction.
- Publication
European Journal of Immunology, 2012, Vol 42, Issue 9, p2263
- ISSN
0014-2980
- Publication type
Article
- DOI
10.1002/eji.201242598