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- Title
Effect of collagen solution application on healing following surgical treatment in colony-bred monkeys.
- Authors
Minabe, Masato; Kagou, Tatsuji; Kodama, Toshiro; Sugaya, Akira; Tamura, Toshiyuki; Hori, Toshio; Watanabe, Yoshihisa
- Abstract
The present study was performed to investigate the effects on periodontal regeneration in flap surgery of acid conditioning and the application of a collagen solution to the root surface. Bone defects were artificially produced in 4 monkeys by removing cortical bone in an apical direction within 4 mm from the alveolar bone crest, following incision and elevation of the buccal gingiva of the second premolars, first molars and lateral incisors of the maxilla and mandibula. After root planing, the root surface at the bottom of the bone defect was notched. The root surfaces were then subjected to various types of root preparation and divided into (1) a group given topical application of collagen solution following acid conditioning, (2) a group given topically applied collagen solution, (3) a group given acid conditioning and (4) controls. The animals were sacrificed 3 or 6 weeks after surgery and histopathologically examined. The results indicated that the method of applying collagen solution to the root surface after acid conditioning in flap surgery promoted suppression of epithelial migration and new cementum formation more effectively than the conventional method of preparation using acid conditioning alone.
- Subjects
COLLAGEN; WOUND healing; PERIODONTIUM regeneration; CONNECTIVE tissues; TEETH; GINGIVA; MONKEYS
- Publication
Journal of Periodontal Research, 1988, Vol 23, Issue 5, p313
- ISSN
0022-3484
- Publication type
Article
- DOI
10.1111/j.1600-0765.1988.tb01423.x