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- Title
Developmental Regulation of Hepatitis B Virus Biosynthesis by Hepatocyte Nuclear Factor 4α.
- Authors
Lie Li; Oropeza, Claudia E.; Sainz Jr., Bruno; Uprichard, Susan L.; Gonzalez, Frank J.; McLachlan, Alan
- Abstract
The host cellular factors that promote persistent viral infections in vivo are, in general, poorly understood. Utilizing the hepatitis B virus (HBV) transgenic mouse model of chronic infection, we demonstrate that the nuclear receptor, hepatocyte nuclear factor 4α (HNF4α, NR2A1), is essential for viral biosynthesis in the liver. The dependency of HBV transcription on HNF4α links viral biosynthesis and persistence to a developmentally regulated transcription factor essential for host viability.
- Subjects
HEPATITIS B virus; BIOSYNTHESIS; LIVER cells; VIRUS diseases; NUCLEAR receptors (Biochemistry); TRANSCRIPTION factors; PATHOGENIC microorganisms; HERPES simplex virus; PAPILLOMAVIRUSES; LABORATORY mice
- Publication
PLoS ONE, 2009, Vol 4, Issue 5, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0005489