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- Title
The Mych Gene Is Required for Neural Crest Survival during Zebrafish Development.
- Authors
Sung-Kook Hong; Tsang, Michael; Dawid, Igor B.
- Abstract
Background: Among Myc family genes, c-Myc is known to have a role in neural crest specification in Xenopus and in craniofacial development in the mouse. There is no information on the function of other Myc genes in neural crest development, or about any developmental role of zebrafish Myc genes. Principal Findings: We isolated the zebrafish mych (myc homologue) gene. Knockdown of mych leads to severe defects in craniofacial development and in certain other tissues including the eye. These phenotypes appear to be caused by cell death in the neural crest and in the eye field in the anterior brain. Significance: Mych is a novel factor required for neural crest cell survival in zebrafish.
- Subjects
GENE expression; NEURAL crest; PHENOTYPES; GENOTYPE-environment interaction; CELL death; NERVOUS system; DEVELOPMENTAL cytology; GENETICS education; ZEBRA danio
- Publication
PLoS ONE, 2008, Vol 3, Issue 4, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0002029