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- Title
The Combination of Naratriptan and Prochlorperazine in Migraine Treatment.
- Authors
Tietjen, Gretchen E.; Athanas, Kathy; Utley, Christine; Herial, Nabeel A.; Khuder, Sadik A.
- Abstract
The article reports on the combination of naratriptan and prochlorperazine in Migraine Treatment. Understanding of the pathophysiological mechanisms of migraine has led to treatment with serotonin agonists, most notably the triptans, the first being sumatriptan 1-3 Naratriptan, a related 5- hydroxytryptamine agonist, is a longer acting triptan, which is well tolerated, and has been associated with a relatively low rate of headache recurrence. Dopamine receptor antagonists have been shown to be highly effective in resolving the headache as well as the nausea associated with migraine and they have a relatively fast onset of action. Prochlorperazine, for example, is well tolerated, has proven efficacy in migraine, at least when given in an intravenous route.
- Subjects
MIGRAINE; NEUROTRANSMITTERS; SEROTONIN; DOPAMINE receptors; NEUROTRANSMITTER receptors; HORMONE receptors
- Publication
Headache: The Journal of Head & Face Pain, 2005, Vol 45, Issue 6, p751
- ISSN
0017-8748
- Publication type
Article
- DOI
10.1111/j.1526-4610.2005.05143_1.x