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- Title
ApoE Polymorphism Is Associated With C-Reactive Protein in Low-HDL Family Members and in Normolipidemic Subjects.
- Authors
Kahri, Juhani; Soro-Paavonen, Aino; Ehnholm, Christian; Taskinen, Marja-Riitta
- Abstract
The study was aimed to compare inflammatory parameters between carriers of apoE4 isoforms (apoE4/3, apoE4/2, and apoE4/4 phenotypes) and those of carrying apoE3 isoform without apoE4 isoform (apoE3/3 phenotypes and apoE2/3 phenotypes). The concentrations of serum hsCRP, sVCAM-1, sICAM-1, and sE-selectin were measured in 211 subjects from Finnish low-HDL families and in 157 normolipidemic subjects. The subjects with apoE4 isoform had lower concentrations of serum hsCRP both in low-HDL family members (p < 0.05) and in normolipidemic subjects (p < 0.01). The differences in serum CRP values remained significant after adjustment for age, BMI, smoking status, hypertension, gender, lipoprotein variables, and family number. We conclude that apoE phenotype has a strong influence on serum CRP values.
- Subjects
APOLIPOPROTEIN E; C-reactive protein; HIGH density lipoproteins; HYPERTENSION; LIPOPROTEINS; SMOKING; HEALTH
- Publication
Mediators of Inflammation, 2006, Vol 2006, p1
- ISSN
0962-9351
- Publication type
Article
- DOI
10.1155/MI/2006/12587