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- Title
No effects of ozonated autohemotherapy on inflammation response in hemodialyzed patients.
- Authors
Tylicki, Leszek; Biedunkiewicz, Bogdan; Rachon, Dominik; Nieweglowski, Tomasz; Hak, Lukasz; Chamienia, Andrzej; Debska-slizien, Alicja; Aleksandrowicz, Ewa; Mysliwska, Jolanta; Rutkowski, Boleslaw
- Abstract
B ackground : Ozone as a strong oxidant may induce an inflammatory response. Aim : The hypothesis was verified as to whether ozonated autohemotherapy using an ozone dose in therapeutic range changes the plasma concentration of C-reactive protein and interleukin-6, markers of inflammation. Methods : In a controlled, single-blind, cross-over study, 12 chronically hemodialyzed patients with peripheral arterial disease were exposed to nine sessions of autohemotherapy with blood exposure to oxygen as a control followed by nine sessions of ozonated autohemotherapy with an ozone concentration of 50 μg/ml. Results : There was no statistical difference between C-reactive protein levels at baseline (1.53±1.01 mg/l), after nine sessions of control autohemotherapy (1.48±0.96 mg/l), and after nine sessions of ozonated autohemotherapy (1.55±0.84 mg/l). There was also no statistical difference between the interleukin-6 serum concentration at baseline (438±118 pg/ml), after nine sessions of control autohemotherapy (444±120 pg/ml), and after nine sessions of ozonated autohemotherapy (466±152 pg/ml). Conclusion : The results of this study suggest that ozonated autohemotherapy using an ozone concentration of 50 μg/ml does not induce an inflammatory response.
- Subjects
HEMODIALYSIS patients; BLOOD transfusion; SURGERY; OXYGEN; BLOOD plasma; C-reactive protein
- Publication
Mediators of Inflammation, 2004, Vol 13, Issue 5/6, p377
- ISSN
0962-9351
- Publication type
Article
- DOI
10.1080/09629350400014131