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- Title
Predictors of Response to 24-Week Telaprevir-Based Triple Therapy for Treatment-Naive Genotype 1b Chronic Hepatitis C Patients.
- Authors
Hiroshi Abe; Akihito Tsubota; Noritomo Shimada; Masanori Atsukawa; Keizo Kato; Koichi Takaguchi; Toru Asano; Yoshimichi Chuganji; Choitsu Sakamoto; Hidenori Toyoda; Takashi Kumada; Tatsuya Ide; Michio Sata; Yoshio Aizawa
- Abstract
We evaluated the genetic variation in rs8099917, substitutions in core amino acid (aa) 70, and the number of aa substitutions in the interferon sensitivity-determining region (ISDR) on the prediction of sustained virological response (SVR) in treatment-naïve hepatitis C virus (HCV) genotype 1b (G1b) patients. This multicenter study involved 150 Asian treatment-naïve patients infected with HCV G1b who received 12 weeks of telaprevir in combination with 24 weeks of peginterferon-a-2b and ribavirin. The baseline and treatment-related factors potentially associated with SVR were determined by multivariate logistic regression analysis. Virological response was analyzed on an intent-to-treat basis. Cessation of the therapy due to adverse effects occurred in only 2 patients, who discontinued the trial at 10 weeks and at 2 weeks due to cerebral infarction and renal impairment, respectively. Among the 150 patients in whom the final virological response was determined, only genotype TT in rs8099917 was identified as a pretreatment predictor (P = 7.38 x 10-4). Achievement of a rapid virological response (RVR), defined as undetectable HCV RNA at week 4 of treatment, was identified as an after-starting-treatment predictor (P = 2.47 x 10-5). However, neither a substitution in core aa 70 nor the number of substitutions in the ISDR affected treatment outcome.
- Subjects
PROTEASE inhibitors; GENOTYPE-environment interaction; FLAVIVIRAL diseases; CEREBROVASCULAR disease; STRUCTURAL equation modeling
- Publication
Gastroenterology Research & Practice, 2014, p1
- ISSN
1687-6121
- Publication type
Article
- DOI
10.1155/2014/549709