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- Title
A Cocrystal of Baicalein and 4,4′-Bipyridine with Zipper-Type Architecture.
- Authors
Liu, Li-xin; Su, Xin; Zhang, Yu-nan; Yin, He-mei; Zhang, Qiang; Feng, Yan-ru; Guo, Ying-xue; Zou, Dong-yu; Liu, Ying-li
- Abstract
A new cocrystal of baicalein, possessing three A-ring-hydroxyl groups and without B-ring-hydroxyl groups and 4,4′-bipyridine (BE·2BPY·H2O) has been prepared and characterized. The structural analyses and Hirshfeld surfaces show that baicalein is hydrogen-bonded to co-crystallized solvent water molecules featuring for example motifs that can be described with graph set R44(8) similar to those reported for the cocrystal of myricetin with 4,4′-bipyridine. A zipper-type architecture is observed in cocrystal BE·2BPY·H2O linking a baicalein, two 4,4′-bipyridine and a solvent water molecules via classical O–H⋯N and O–H⋯O and non-classical C–H⋯O hydrogen bonds into 2D sheets. Additionally, the cocrystal shows better solubility in 0.1 M HCl in comparison to pure baicalein. Cocrystal of baicalein with zipper-type architecture shows improved solubility compared to baicalein.
- Subjects
HYDROGEN bonding; SOLUBILITY; SURFACE analysis; SOLVENTS
- Publication
Journal of Chemical Crystallography, 2021, Vol 51, Issue 3, p363
- ISSN
1074-1542
- Publication type
Article
- DOI
10.1007/s10870-020-00853-2