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- Title
Wnt10b Increases Postnatal Bone Formation by Enhancing Osteoblast Differentiation.
- Authors
Bennett, Christina N.; Hongjiao Ouyang; Ma, Yanfei L.; Qingqiang Zeng; Gerin, Isabelle; Sousa, Kyle M.; Lane, Timothy F.; Krishnan, Venkatesh; Flankenson, Kurt D.; MacDougald, Ormond A.
- Abstract
The article presents medical research that found Wnt10b increases postnatal bone formation via the enhancement of osteoblast cell differentiation in mice. Radiography, computed tomography, static histomorphometry, and dynamic histomorphometry were used in the quantitative assessment of bone variables. There were increased mandibular bone and impaired eruption of incisors during postnatal development were evident in mice whose Wnt10b is expressed from the human osteocalcin promoter.
- Subjects
MEDICAL research; WNT genes; BONE growth; CELL differentiation; BONE cells; LABORATORY mice
- Publication
Journal of Bone & Mineral Research, 2007, Vol 22, Issue 12, p1924
- ISSN
0884-0431
- Publication type
Article
- DOI
10.1359/JBMR.070810