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- Title
Molecular detection of Parachlamydia-like organisms in cerebrospinal fluid of patients with multiple sclerosis.
- Authors
Contini, C.; Seraceni, S.; Cultrera, R.; Castellazzi, M.; Granieri, E.; Fainardi, E.
- Abstract
The presence of Chlamydia-like organism DNA was investigated by polymerase chain reaction (PCR) in cerebrospinal fluid (CSF) samples from 27 patients previously found positive for Chlamydia pneumoniae DNA: 12 with multiple sclerosis (MS), grouped according to clinical and magnetic resonance imaging (MRI) evidence of disease activity, 8 with other inflammatory neurological disorders and 7 with noninflammatory neurological disorders. PCR evidence of Chlamydia-like organisms in CSF was observed only in two relapsing-remitting MS patients with clinical and MRI disease activity. These findings suggest a possible association between C. pneumoniae and Chlamydia-like organism brain infections as a cofactor in MS development.
- Subjects
MULTIPLE sclerosis; CHLAMYDIA; CEREBROSPINAL fluid; STRESS management; CLINICAL trials; THERAPEUTICS
- Publication
Multiple Sclerosis (13524585), 2008, Vol 14, Issue 4, p564
- ISSN
1352-4585
- Publication type
Article
- DOI
10.1177/1352458507085796