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- Title
Protective Efficacy of a Live Attenuated Vaccine against Argentine Hemorrhagic Fever.
- Authors
Maiztegui, Julio I.; McKee, Kelly T.; Oro, Julio G. Barrera; Harrison, Lee H.; Gibbs, Paul H.; Feuillade, Maria R.; Enria, Delia A.; Briggiler, Ana M.; Levis, Silvana C.; Ambrosio, Ana M.; Halsey, Neal A.; Peters, Clarence J.
- Abstract
Argentine hemorrhagic fever (AHF), caused by the arenavirus Junin, is a major public health problem among agricultural workers in Argentina. A prospective, randomized, double-blind, placebo- controlled, efficacy trial of Candid 1, a live attenuated Junin virus vaccine, was conducted over two consecutive epidemic seasons among 6500 male agricultural workers in the AHF-endemic region. Twenty-three men developed laboratory-confirmed AHF during the study; 22 received placebo and 1 received vaccine (vaccine efficacy 95%; 95% confidence interval [CI], 82%–99%). Three additional subjects in each group developed laboratory-confirmed Junin virus infection associated with mild illnesses that did not fulfill the clinical case definition for AHF, yielding a protective efficacy for prevention of any illness associated with Junin virus infection of 84% (95% CI, 60%–94%). No serious adverse events were attributed to vaccination. Candid 1, the first vaccine for the prevention of illness caused by an arenavirus, is safe and highly efficacious.
- Publication
Journal of Infectious Diseases, 1998, Vol 177, Issue 2, p277
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1086/514211