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- Title
Horizontal and vertical transmission of human immunodeficiency virus type 1 dual infections caused by viruses of subtypes B and C.
- Authors
Janini, Luiz M.; Tanuri, Amilcar; Schechter, Mauro; Peralta, Jose M.; Vicente, Ana C. P.; Torre, Nick Dela; Pieniazek, Norman J.; Luo, Chi-cheng; Ramos, Artur; Soriano, Vincent; Schochetman, Gerald; Rayfield, Mark A.; Pieniazek, Danuta; Janini, L M; Tanuri, A; Schechter, M; Peralta, J M; Vicente, A C; Dela Torre, N; Pieniazek, N J
- Abstract
This article describes a case of horizontal (heterosexual) and subsequent vertical (mother to infant) transmission of 2 human immunodeficiency viruses type 1 (HIV-1) subtypes. Dual infection in a husband, his wife, and their child was initially detected by use of a restriction fragment length polymorphism assay of the proviral protease in peripheral blood mononuclear cells. The simultaneous presence of highly similar sets of HIV-1 subtypes B and C infecting the 3 family members was confirmed by DNA sequence analysis of pol, gag, and env genes. These data, together with available epidemiologic information, may indicate that the husband's high-risk sexual behavior was the source of dual infections. Because his wife did not report such activities, it was likely that he passed HIV- 1 strains to his spouse, who subsequently transmitted them to their child.
- Publication
Journal of Infectious Diseases, 1998, Vol 177, Issue 1, p227
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1086/517360