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- Title
Measles Virus-Specific Functional Antibody Responses and Viremia during Acute Measles.
- Authors
Forthal, Donald N.; Landucci, Gary; Habis, Angelique; Zartarian, Minas; Katz, Jacob; Tilles, Jeremiah G.
- Abstract
Antibody titers measured in functional and immunofluorescent assays were compared with proportions of peripheral blood mononuclear cells infected with measles virus in 8 adults with measles. In addition, a syncytium inhibition assay (SIA) for measuring neutralizing antibody using low-passage virus was compared with a standard plaque neutralization test (PNT). Antibody-dependent cellular cytotoxicity (ADCC) antibody rose later but attained higher titer than neutralizing, antibody-dependent complement-mediated lysis, IgM, or IgG antibodies. When titer changes between specimens from each patient obtained on different days were compared, only ADCC (r = .81, P = .026) and IgM (r = .81, P = .027) antibodies correlated with reductions in viremia. SIA and PNT correlated well (r = .93, P < .001). ADCC may be an important defense against measles. The delay in ADCC antibody relative to other antibodies is unique among viruses studied. The SIA is a useful alternative to the PNT for measuring measles neutralizing antibody.
- Publication
Journal of Infectious Diseases, 1994, Vol 169, Issue 6, p1377
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1093/infdis/169.6.1377