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- Title
Acute Myocardial Effects of Chloramphenicol in Newborn Pigs: A Possible Insight into the Gray Baby Syndrome.
- Authors
Werner, John C.; Whitman, Victor; Schuler, H. Gregg; Fripp, Raymond R.; Rannels, Anne M.; Kasales, Claudia J.; LaNoue, Kathryn F.
- Abstract
Mechanical function and mitochondrial respiration were observed in newborn pig hearts in the presence of chloramphenicol. Isolated perfused hearts exposed to chloramphenicol (25, 50, or 100 µg/ml) demonstrated acute reductions in pressure development and cardiac output accompanied by elevated left atrial filling pressure. The effects of chloramphenicol and chloramphenicol succinate (25, 50, 100, or 200 µg/ml) on oxidative activity of isolated mitochondria were also investigated. With unesterified chloramphenicol, inhibition of state 3 respiration was most apparent when glutamate and palmity1carnitine were supplied as substrates. Inhibition of mitochondrial oxidation of succinate or glutamate was only detectable at 200 µg/ml. Inhibition of α-ketoglutarate oxidation was not seen at any concentration of antibiotic studied. Chloramphenicol succinate most strongly inhibited state 3 oxidation of succinate and α-ketoglutarate and had relatively mild effects on oxidation of glutamate and palmitylcarnitine. Succinate oxidation by submitochondrial particles was unaffected by chloramphenicol succinate, a result suggesting interference with succinate transport.
- Publication
Journal of Infectious Diseases, 1985, Vol 152, Issue 2, p344
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1093/infdis/152.2.344