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- Title
Depletion of CD38‐positive regulatory T cells by anti‐CD38 monoclonal antibodies induces a durable response to SARS‐CoV‐2 vaccination in patients with plasma cell dyscrasia.
- Authors
Terao, Toshiki; Naduka, Takashi; Ikeda, Daisuke; Fukumoto, Ami; Kamura, Yuya; Kuzume, Ayumi; Tabata, Rikako; Tsushima, Takafumi; Miura, Daisuke; Narita, Kentaro; Takeuchi, Masami; Matsue, Kosei
- Abstract
Summary: This study reports the relationship between CD38+ regulatory T cells (Tregs) and messenger RNA coronavirus disease 2019 (mRNA‐COVID‐19) vaccination in 60 patients with plasma cell dyscrasia. Patients treated with anti‐CD38 monoclonal antibodies (mAbs) had significantly lower CD38+ Tregs than those not treated (0.9 vs. 13.2/μl). Late‐responders, whose antibody titres increased from weeks 4–12 after the second vaccination, had significantly lower CD38+ Treg counts than non‐late‐responders (2.5 vs. 10.3/μl). Antibody titres in patients with lower CD38+ Treg levels were maintained from weeks 4–12 but decreased in those with higher CD38+ Treg levels. Therefore, depletion of CD38+ Tregs by anti‐CD38 mAbs may induce a durable response to mRNA‐COVID‐19 vaccination.
- Subjects
REGULATORY T cells; MONOCLONAL antibodies; PLASMA cells; COVID-19; CD38 antigen
- Publication
British Journal of Haematology, 2022, Vol 197, Issue 4, p417
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/bjh.18079