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- Title
Impact of chronic lymphocytic leukaemia on melanoma outcomes: A retrospective case‐control study.
- Authors
Jobson, Dale; McCormack, Christopher J.; Mar, Victoria; Tam, Constantine; Henderson, Michael A.
- Abstract
Summary: With new, effective treatments for chronic lymphocytic leukaemia (CLL) the impact of second malignancies is increasingly important. We performed a retrospective case‐controlled study examining the effect of CLL and its treatment on melanoma‐specific survival and recurrence. A total of 56 patients with melanoma with CLL were matched 1:1 to patients without CLL for age, date of diagnosis, gender and melanoma tumour, node, metastasis (TNM) stage. Multivariate analysis found CLL was associated with significantly worse melanoma‐specific mortality (hazard ratio [HR] 2.46, 95% confidence interval [CI] 1.27–4.74, p = 0.007) and recurrence (HR 3.44, 95% CI 1.79–6.63, p < 0.001). Patients with CLL had poor immunotherapy tolerance and prior CLL treatment was not associated with melanoma outcomes.
- Subjects
CHRONIC leukemia; LYMPHOCYTIC leukemia; MELANOMA; CASE-control method; CHRONIC lymphocytic leukemia; RETROSPECTIVE studies
- Publication
British Journal of Haematology, 2022, Vol 197, Issue 3, p320
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/bjh.18090