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- Title
Predicting risk severity and response of fetal neonatal alloimmune thrombocytopenia.
- Authors
Salomon, Ophira; Rosenberg, Nurit
- Abstract
Fetal neonatal alloimmune thrombocytopenia ( FNAIT) is a devastating bleeding disorder in the fetus or neonate caused by transplacental transport of maternal alloantibodies to paternal-derived antigen on fetal platelets. In Caucasians, up to 80% of FNAIT cases result from maternal immunization to human platelet antigen ( HPA)-1a. New methods have developed facilitating detection of common and private antibodies against HPAs triggering FNAIT. Understanding the pathogenesis of FNAIT made it possible to develop a novel strategy to treat this disorder. To date, recombinant monoclonal antibodies directed against the β3 integrin and Fc receptors have been tested in a mouse model of FNAIT, and seem to be promising. Whether those novel treatments will eventually replace the conventional high dose immunoglobulin G in women with FNAIT is yet unknown.
- Subjects
NEONATAL mortality; THROMBOCYTOPENIA; ANTIGENS; CARCINOGENESIS; IMMUNOGLOBULIN G
- Publication
British Journal of Haematology, 2013, Vol 162, Issue 3, p304
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/bjh.12372