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- Title
Cardiac conduction defects associate with mutations in SCN5A.
- Authors
Schott, Jean-Jacques; Alshinawi, Connie; Kyndt, Florence; Probst, Vincent; Hoorntje, Theo M.; Hulsbeek, Miriam; Wilde, Arthur A.M.; Escande, Denis; Mannens, Marcel M.A.M.; Le Marec, Hervé
- Abstract
Defines progressive cardiac conduction defect (PCCD) or Lenegre of Lev disease, as one of the most common cardiac disturbances. Identification of the SCN5A as the first gene whose mutation causes an isolated cardiac conduction defect; Use of a genetic approach in a French family in which Lenegre-Lev disease was diagnosed; Increase in the conduction defect of patients in severity with age.
- Subjects
HEART diseases; AGE; GENETIC mutation
- Publication
Nature Genetics, 1999, Vol 23, Issue 1, p20
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/12618