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- Title
Influence of Reloading on Recovery from Disuse Atrophy of the Rat Soleus Muscle --Site-related Differences.
- Authors
NISHIKAWA, MASASHI; YAMAZAKI, TOSHIAKI; ZUSHI, KAZUMI
- Abstract
[Purpose] We investigated the effects of intervention on the recovery process related to reloading after disuse atrophy of the rat soleus muscle with respect to sites. [Methods] Eight-week-old male Wistar rats were divided into 7 groups (n=7): 1) control group under standard breeding (C14 group), 2) control group on the day of initiation (C0 group), 3) hind-limb suspension group (H14 group), and 4) standard breeding (reloading) groups after hind-limb suspension (R3, R5, R7, and R14 groups). After the completion of the experiment, the right soleus muscle was cut into 4 to prepare origin, proximal, middle, and distal samples. Subsequently, the transverse muscle fiber area was measured. [Results] In the H14 group, the transverse muscle fiber area was significantly lower than in the C14 group. In this group, the value for the distal region was significantly higher. The transverse muscle fiber area increased with the interval of reloading. However, in the R groups other than the R14 group, the values for the distal region were significantly higher than those for the proximal region. [Conclusion] The results suggest that there are differences in the responsiveness to hind-limb suspension and subsequent reloading among longitudinal sites of the rat soleus muscle.
- Subjects
ATROPHY; RATS; MUSCLES; EXPERIMENTS; VALUES (Ethics)
- Publication
Rigakuryoho Kagaku, 2011, Vol 26, Issue 1, p133
- ISSN
1341-1667
- Publication type
Article
- DOI
10.1589/rika.26.133