We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Age dependence of the biosynthesis of intercellular matrix macromolecules of rabbit aorta in organ culture and cell culture.
- Authors
Moczar, Madeleine; Ouzilou, Jackie; Courtois, Yves; Robert, Ladislas; Moczar, M; Ouzilou, J; Courtois, Y; Robert, L
- Abstract
The age dependence of the relative rate of biosynthesis of intercellular matrix macromolecules was studied in organ culture and cell culture obtained from aortas of newborn, young and adult rabbits. In organ culture there was a strong decrease with age of the rate of incorporation of (14C)-lysine and (3H)-glucosamine in all macromolecular fractions. Neosynthesis of elastin could be demonstrated by the isolation of labelled demosine at all ages. In cell cultures derived from newborn and adult aortas, no decrease in total incorporation was noticed. The pattern of synthesis and secretion of glycosaminoglycans and glycoproteins did however change with age. These results suggest the existence of matrix-dependent and of a matrix-independent regulation of the relative rate of synthesis of matrix macromolecules.
- Publication
Gerontology, 1976, Vol 22, Issue 6, p461
- ISSN
0304-324X
- Publication type
journal article
- DOI
10.1159/000212158