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- Title
Tip 1 diyabetes mellitus tanılı bir olguda rinoserebral mukormikoz.
- Authors
ALICI, Ayşe; FIRTINA, Aytekin; YENİŞEHİRLİ, Gülgün; ERDİM, İbrahim; AKÇAY, Elif
- Abstract
Mucormycosis is an invasive fungal infection caused by mold fungi of the Mucarales order, which progresses quite rapidly and has a high mortality despite effective treatment. Conditions such as diabetes mellitus, cancer immunotherapy, stem cell transplantation are risk factors for mucormycosis. In this study, we aimed to report a case of rhinocerebral mucormycosis that we followed in our hospital. A 20-year-old female patient with known type 1 diabetes was admitted to the otolaryngology outpatient clinic of our hospital with complaints of sore throat, neck, headache, weakness and numbness on her face. The patient was admitted to the ward due to the presence of bloody nasopharyngeal discharge in the physical examination. The patient, who entered diabetic ketoacidosis on the first day of hospitalization and disorder of consciousness, was admitted to the intensive care unit. In the magnetic resonance (MR) imaging of the patient, fluid signals in the paranasal sinuses and both mastoid cells and areas suggestive of mucormycosis or invasive Aspergillus were observed in the nasopharynx and soft tissues adjacent to the nasopharynx. Acute ischemic lesions were observed in the diffusion MRI of the patient. In the culture of the nasopharyngeal swab, hyphal structures without septa and branching at right angles were seen and it was decided that they were mucareles. In the nasopharyngeal biopsy material taken from the patient, hyphal structures and rhizoid structures were seen pathologically suggestive of mucormycosis. The patient was started on amphotericin B 250 mg treatment. The patient died on the 35th day of her hospitalization, not responding to cardiopulmonary resuscitation. It should be kept in mind that such opportunistic fungal infections can be seen in patients with suppressed immune system such as diabetes mellitus, and it will be difficult to control the infection due to its rapid spread.
- Subjects
TYPE 1 diabetes; STEM cell transplantation; MYCOSES; OPPORTUNISTIC infections; DIFFUSION magnetic resonance imaging; THROAT
- Publication
Turkish Bulletin of Hygiene & Experimental Biology / Türk Hijyen ve Deneysel Biyoloji, 2023, Vol 80, Issue 1, p109
- ISSN
0377-9777
- Publication type
Case Study
- DOI
10.5505/TurkHijyen.2023.70845