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- Title
Caveats in interpreting SARS‐CoV‐2 IgM<sup>+</sup>/IgG<sup>−</sup> antibody profile in asymptomatic health care workers.
- Authors
Valdivia, Arantxa; Torres, Ignacio; Huntley, Dixie; Alcaraz, María Jesús; Albert, Eliseo; Solano de la Asunción, Carlos; González, Carmelo; Ferrer, Josep; Navarro, David
- Abstract
Caveats in interpreting SARS-CoV-2 IgM+/IgG- antibody profile in asymptomatic health care workers Serological testing is increasingly recognized as a useful tool for management of the coronavirus disease-2019 (COVID-19) pandemic.1 Cross-sectional serosurveys provide information on exposure levels in a target population, which is helpful for designing public health strategies to blunt community transmission.2 To maximize sensitivity, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroprevalence could be defined as positivity of any antibody isotype (IgG, IgM, or IgA), as detected by enzyme-linked immunosorbent assays or chemiluminescent immunoassays (CLIA).3-5 Theoretically, however, this approach may lead to false-positive results outnumbering true-positive ones in low prevalence settings, even when highly specific assays are used. Qualitative assessment of SARS-CoV-2-specific antibody avidity by lateral flow immunochromatographic IgG/IgM antibody assay.
- Subjects
MEDICAL personnel; SARS-CoV-2
- Publication
Journal of Medical Virology, 2021, Vol 93, Issue 2, p634
- ISSN
0146-6615
- Publication type
Article
- DOI
10.1002/jmv.26400